“I love this show … this show has been my life and I love it enough to know when it’s time to say goodbye,” said Winfrey. “Twenty-five years feels right in my bones and my spirit. It’s the perfect number, the exact right time.”

On Thursday, Harpo Productions confirmed that the woman appointed The Queen of Talk has decided to end the groundbreaking Oprah Winfrey Show she has helmed since 1985. Oprah will formally announce news of her departure on Friday. The final episode of The Oprah Winfrey Show is scheduled to air in May 2011.

“I was really hurt, really, really hurt,” Givens told Winfrey of the TV show host’s and her audience’s reaction to the boxer’s October Oprah show comments about the actress’ 1988 Barbara Walters interview. Tyson previously claimed on Oprah’s show that Givens lied during the interview and he added, “At that particular moment, I truly wanted to sock her, but I didn’t do it,” as the “Oprah” audience laughed.

Robin, who claims Mike battered her throughout their shortlive marriage is a spokesperson for the National Domestic Violence Hotline, said the reaction was difficult to take.

“I just wanted you… When he said ‘I’ve socked her before,’ to say, ‘That’s not right!’ And it wasn’t right and it was painful,” she said tearing up. “There are so many women like me out there… if you hear laughter about it, it lightens it.”

Domestic violence has been a hot topic on Oprah recently, with The Queen of Talk feuding with crooner Chris Brown after he said he was upset she did not help him out following his assault on Rihanna in February, and for doing a show on domestic violence not long after the incident. More recently, O pulled the plug on an interview with gospel legend BeBe Winans after coming under fire for taping an interview with the star, who is facing domestic assault charges.

“It further demonstrates the fact that Oprah continues to be a strong voice against domestic violence and that she’s willing to take the steps necessary to defend the defenseless,” Debra said in a statement last week.

Earlier in this year, Oprah devoted an entire hour to domestic violence after Rihanna was beaten by Chris Brown.

“You don’t want to know?” Oprah asked

“If I know, then there might be a blame for it,” Iron Mike replied. “And if there’s somebody to blame for it, there will be a problem.”

He added: “My first instinct was a lot of rage, you know, and I was so happy that I had the tools in life, you know, to not go in that direction because I’ve been that direction. I know where that’s gonna lead me. I know I’m not gonna win.”

On Monday, Whitney — who is staging a career comeback with the release of her album in 7 years, I Look To You – told Oprah that the crooner wasn’t physically abusive but that “he slapped me once but he got hit on the head three times by me.”

Whitney, 46, says she “was horrified he spit on me, in my face” and that left her “very hurt, very angry.”

The star says she was attracted to Brown, who she married in a lavish ceremony in 1992, because he had control in their relationship.

“He was my drug,” Whitney tells Oprah. “I didn’t do anything without him.” “Something happens to a man when a woman has that much fame. … I tried to play down all the time. I used to say, ‘I’m Mrs. Brown, don’t call me Houston.’”

Whitney Houston goes one-on-one with the Queen of Talk i a two-part appearance premiering on The Oprah Winfrey Show this Monday, Sept. 14.

In this sneak peek video of Oprah Winfrey’s one-on-one interview with legendary singer Whitney Houston, the singer describes the day her mother, gospel legend Cissy Houston, staged an intervention to get the star into rehab — with the help of the local sheriff.

Oprah chats with Whitney on the 24th season premiere of The Oprah Winfrey Show Monday, Sept. 14 and Tuesday, Sept. 15.